The Hydrolysis of Vitamin B12. Studies with Model Amides

R Bonnett, JA Raleigh, DG Redman

Index: Bonnett,R. et al. Journal of the American Chemical Society, 1965 , vol. 87, # 7 p. 1600 - 1607

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Citation Number: 4

Abstract

The suitability of certain cyclopentylacylamides as models for the steric situations of the amide groups in vitamin BI2 is discussed. The syntheses of (l-methylcyclopentj. l) acetamide, p-(1-methylcyclopenty1) propion-amide, and~-(trans-2, 2, 3-trimethylcyclopentyl) propion- amide are described, and the rates of hydrolysis of these and other model amides in aqueous hydrochloric acid-dioxune at 50'are recorded. Aquocobalamin has been ...