Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1, 3, 4-oxadiazole and 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazole derivatives

G Chawla, U Kumar, S Bawa…

Index: Chawla, Gita; Kumar, Umesh; Bawa, Sandhya; Kumar, Jagdish Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 5 p. 658 - 665,8

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Citation Number: 9

Abstract

Several 2, 5-disubstituted-1, 3, 4-oxadiazoles (4a–f) and 3, 6-disubstituted-1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazoles (7a–f) were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound 7c showed excellent anti- inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid ...