Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl) indazole (YC-1) as novel anti-leukemia agents

LC Chou, LJ Huang, JS Yang, FY Lee, CM Teng…

Index: Chou, Li-Chen; Huang, Li-Jiau; Yang, Jai-Sing; Lee, Fang-Yu; Teng, Che-Ming; Kuo, Sheng-Chu Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1732 - 1740

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Citation Number: 64

Abstract

As part of our continuing search for potential anticancer drug candidates in YC-1 analogs, several 1-benzyl-3-(substituted aryl)-5-methylfuro [3, 2-c] pyrazoles were synthesized and evaluated for their cytotoxicity against HL-60 cell line. Among these compounds, 1-benzyl-3- (5-hydroxymethyl-2-furyl)-5-methylfuro [3, 2-c] pyrazole (1) showed more potency than YC-1. Through investigation of action mechanism, it was found that compound 1 induced ...