Abstract The synthesis of a range of mono spiro and dispiro 1, 2, 4, 5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC 50 s versus colon (HT29-AK and leukemia (HL60) cell lines.
![3-(3-methyl-1,2,4,5-tetraoxa-spiro[5.5]undec-3-yl)-propionic acid ethyl ester Structure](https://image.chemsrc.com/caspic/032/923267-27-0.png)
![3-(3-methyl-1,2,4,5-tetraoxaspiro[5.5]undecan-3-yl)propanoic acid Structure](https://image.chemsrc.com/caspic/494/923267-28-1.png)
