Synthesis of an 11-cis-locked biotinylated retinoid for sequestering 11-cis-retinoid binding proteins

…, Y Itagaki, K Nakanishi, N Nesnas

Index: Matsuda, Hiroko; Zhang, Shenglong; Holmes, Andrea E.; Krane, Sonja; Itagaki, Yasuhiro; Nakanishi, Koji; Nesnas, Nasri Canadian Journal of Chemistry, 2006 , vol. 84, # 10 p. 1363 - 1370

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Abstract

The synthesis of a seven-membered ring locked analogue of 11-cis-retinol, tethered to a cross-linking moiety on C-15 and a lysine-extended biotin on the C-3, was accomplished for its utilization as a probe to fish out retinol binding proteins that may be involved in the reisomerization of retinal from all-trans to 11-cis in the visual cycle. Key words: retinoids, biotin, 11-cis-locked, cross-linking, retinol binding proteins.