Pyrido [3', 2': 4, 5] thieno [3, 2-d]-N-triazines: A new series of orally active antiallergic agents

RD Youssefyeh, RE Brown, J Wilson…

Index: Youssefyeh, Raymond D.; Brown, Richard E.; Wilson, Jeffrey; Shah, Uresh; Jones, Howard; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1639 - 1643

Full Text: HTML

Citation Number: 42

Abstract

To 2.0 g (0.008 mol) of 22 in 60 mL of 2-propanol at room temperature were added 0.72 g (0.008 mol) of 3-amino-1, 2-propanediol and 0.8 g (0.008 mol) of triethylamine. After the mixture was stirred for 16 h, the solvent was removed on the rotary evaporator, and the residue was flash chromatographed on silica gel (230-400 mesh) with 10% methanol/chloroform elution. The product had Rf 0.4 and was isolated as a yellow solid ( ...