Triethyl fluorophosphonoacetate and triethyl difluorophosphonoacetate are directly synthesized from triethyl phosphonoacetate by treatment with NaH and 1-chloromethyl-4- fluoro-1, 4-diazoniabicyclo [2.2. 2] octane bis (tetrafluoroborate)(Selectfluor®). Contrary to a recent report [CJ Hamilton, SM Roberts, J. Chem. Soc., Perkin Trans. 1 (1999) 1051–1056], the reaction proceeded in THF without the need for DMF as a co-solvent. This method is ...
