An attempt was made to synthesize a series of non-cytotoxic low molecular weight meta- substituted aromatic ethers (2–4, 5–7) and some of their bioisosteres (14–16) and to evaluate their activity on the activation of human complement (classical pathway) and their intrinsic hemolytic activity. The in vitro assay results of the inhibition of complement- mediated hemolysis by these analogues indicate that the aldehydic meta substituted ...
