Fluorescence Reagents for Labelling of Biomolecules. Part I. Synthesis and Spectral Characterization of 2-and 4-Substituted 9-Isothiocyanatoacridines

…, D Sabolová, P Kristian, J Imrich…

Index: Mazagova, Dana; Sabolova, Danica; Kristian, Pavol; Imrich, Jan; Antalik, Marian; Podhradsky, Dusan Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 1 p. 203 - 212

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Citation Number: 20

Abstract

Abstract 9-Isothiocyanatoacridines VIII-XIV were prepared from the corresponding 9- chloroacridines I-VII. The IR, 1 H NMR, 13 C NMR and fluorescence spectra of the products are given. The 13 C NMR chemical shifts of the C-9 ipso carbon atom exhibit a trend that is in accord with the Hammett constants of substituents bonded to the C-2 carbon. Effect of these substituents on the chemical shift of C-NCS was only small. The dependence of ...