Carbon-carbon bond formation is the essence of organic synthesis; the Henry reaction, an aldol-type reaction, represents one of the classical CC bond-forming processes, and its variants have been used extensively in many important syntheses. 1-19 The classical nitroaldol reaction is performed, as routine procedure, in presence of a base (Scheme 1) in an organic solvent. Since basic reagents are also catalysts for the aldol condensation and ...
