Tetrahedron Letters

Cannabis XXVI. Total synthesis of cannabifuran

J Novak, CA Salemink

Index: Novak, J.; Salemink, C. A. Tetrahedron Letters, 1983 , vol. 24, # 1 p. 101 - 102

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Citation Number: 8

Abstract

Summary: The naturally occurring dibenzofuran cannabifuran (10) has been synthesized- from 2, 3-dimethoxy-p-toluic acid and Z-bromoolivetol dimethyl ether. In the key step, the aryl- aryl bond has been formed via a methoxy displacement in the aryloxazoline (1).-The final furan ring closure in (8) to (10) was accomplished by the HI/Ac20--reagent. we wish to report the total synthesis of cannabifuran (IO), a naturally occurring--dibenzofuran, isolated as a ...