NMR??Guided Fragment??Based Approach for the Design of tRNALys3 Ligands

F Chung, C Tisné, T Lecourt, F Dardel…

Index: Chung, Florence; Tisne, Carine; Lecourt, Thomas; Dardel, Frederic; Micouin, Laurent Angewandte Chemie - International Edition, 2007 , vol. 46, # 24 p. 4489 - 4491

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Citation Number: 36

Abstract

RNA is a key player in many cellular processes and in viral infection, and is therefore an attractive target in drug discovery.[1] The clinical utility of antibiotic drugs that target the bacterial ribosome has demonstrated that RNA can indeed be a relevant target.[2] Among other druggable RNA targets, functional sites within the genomic RNA of HIV-1, such as the transactivation-responsive element (TAR), the Rev-responsive element (RRE), or the ...