A number of novel guanine derivatives containing heterocyclic moieties at the O 6-position have been synthesized using a purine quaternary salt which reacts with alkoxides under mild conditions. Initially O 6-substituents were investigated in which the benzene ring of the known agent, O 6-benzylguanine, was replaced by unsubstituted heterocyclic rings. The ability of these agents to inactivate the DNA repair protein O 6-alkylguanine-DNA ...
![1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI) Structure](https://image.chemsrc.com/caspic/437/76470-45-6.png)
