Elemental fluorine: Part 20. Direct fluorination of deactivated aromatic systems using microreactor techniques

RD Chambers, MA Fox, G Sandford, J Trmcic…

Index: Chambers, Richard D.; Fox, Mark A.; Sandford, Graham; Trmcic, Jelena; Goeta, Andres Journal of Fluorine Chemistry, 2007 , vol. 128, # 1 p. 29 - 33

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Citation Number: 48

Abstract

Fluoroarene derivatives have been used for many applications in the life-science and materials industries [2] and are usually synthesised on the commercial scale by either Balz–Schiemann-type fluorodediazotisation or halogen exchange ('Halex') methodologies [3]. Since both of these strategies require multi-step synthetic sequences, a more direct method for the synthesis of fluoroaromatic systems is the transformation of carbon–hydrogen to ...