A Shimizu Non??Aldol Approach to the Formal Total Synthesis of Palmerolide A

…, P Gowrisankar, KP Kaliappan

Index: Pujari, Sandip A.; Gowrisankar, Parthasarathy; Kaliappan, Krishna P. Chemistry - An Asian Journal, 2011 , vol. 6, # 11 p. 3137 - 3151

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Citation Number: 16

Abstract

Abstract A formal total synthesis of palmerolide A has been accomplished by assembling three fragments by means of successive Julia–Kocienski olefination, Yamaguchi esterification, and ring-closing metathesis (RCM). Our initial efforts to combine the first two fragments through a Julia–Kocienski reaction between a secondary sulfone and a ketone were not successful; nevertheless, it was feasible between a primary sulfone and ...