Several critical features in the strategy for synthesis of 2 (Scheme I) included (1) the formation bond g to secure the cyclopropylspirocyclohexadienone 2 from the penultimate intermediate 3 through an intramolecular para alkylation, 6 (2) the aromatic substitution pattern of 4 to regiospecifically direct introduction of the 8-methylindolic group of 3, and (3) an efficient, regiospecific synthesis of 6-hydroxyindolines 4. Commercially available 4- ...
