Aminothiazole inhibitors of HCV RNA polymerase

GW Shipps, Y Deng, T Wang, J Popovici-Muller…

Index: Shipps Jr., Gerald W.; Deng, Yongqi; Wang, Tong; Popovici-Muller, Janeta; Curran, Patrick J.; Rosner, Kristin E.; Cooper, Alan B.; Girijavallabhan, Viyyoor; Butkiewicz, Nancy; Cable, Michael Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 115 - 119

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Citation Number: 22

Abstract

Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.