Discovery of novel 2-anilinopyrazolo [1, 5-a] pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke

…, S Kobayashi, Y Komatsu, S Kikuchi, E Tsuji…

Index: Mukaiyama, Harunobu; Nishimura, Toshihiro; Shiohara, Hiroaki; Kobayashi, Satoko; Komatsu, Yoshimitsu; Kikuchi, Shinji; Tsuji, Eiichi; Kamada, Noboru; Ohnota, Hideki; Kusama, Hiroshi Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 6 p. 881 - 889

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Citation Number: 19

Abstract

We synthesized a series of novel 2-anilinopyrazolo [1, 5-a] pyrimidine derivatives and evaluated their ability to inhibit c-Src kinase; 7-(2-amino-2-methylpropylamino)-5- cyclopropyl-2-(3, 5-dimethoxyphenylamino) pyrazolo [1, 5-a] pyrimidine-3-carboxamide 7o and 7-(2-amino-2-methylpropylamino)-2-(3, 5-dimethoxyphenylamino)-5-methylpyrazolo [1, 5-a] pyrimidine-3-carboxamide 7f showed potent inhibitory activity. Compound 7f inhibited ...