Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles

…, SW Yee, M Jayne, MP Coogan, C Simons

Index: Pautus, Stephane; Yee, Sook Wah; Jayne, Martyn; Coogan, Michael P.; Simons, Claire Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 11 p. 3643 - 3653

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Citation Number: 51

Abstract

Methodology previously described by our group was applied to the preparation of a series of 4-alkyl/aryl-substituted 1-[benzofuran-2-yl-phenylmethyl]-1H-triazoles. The [1, 2, 4]-triazole derivatives were prepared for a range of alkyl and aryl substituents, and for the 4-methyl, 4- ethyl, 4-ipropyl, 4-tbutyl, 4-phenyl and 4-chlorophenyl derivatives, the minor [1, 3, 4]-triazole isomer also isolated. All the triazole derivatives were evaluated for CYP26A1 inhibitory ...