2-phenylimidazopyridines, a new series of golgi compounds with potent antiviral activity

…, RJ Thomas, JC Sircar, ML Richards

Index: Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Tieu, Kenneth K.; Sircar, Jagadish C. Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6451 - 6454

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Citation Number: 17

Abstract

Drugs targeted to viral proteins are highly vulnerable to the development of resistant strains. We previously characterized a group of 2-phenylbenzimidazole compounds for their activity against allergy and asthma and more recently established the Golgi as their probable site of action. Herein we describe their activity against the propagation of several virus types through an action on the host cell. The most potent derivatives are the novel 2- ...