Synthesis and antitumor activity of β-carboline 3-(substituted-carbohydrazide) derivatives

VA Barbosa, ASN Formagio, FC Savariz…

Index: Barbosa, Valeria Aquilino; Formagio, Anelise S. Nazari; Savariz, Franciele Cristina; Foglio, Mary Ann; Spindola, Humberto Moreira; De Carvalho, Joao Ernesto; Meyer, Emerson; Sarragiotto, Maria Helena Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6400 - 6408

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Citation Number: 25

Abstract

A series of β-carboline derivatives bearing a substituted-carbohydrazide moiety at C-3 were synthesized and evaluated for their antitumor activity against eight human cancer cell lines. The β-carboline N-(substituted-benzylidene) carbohydrazides showed, in general, a greater antitumor activity than their N-(alkylidene) carbohydrazide analogues. The N9-methylation of β-carboline N-(substituted-benzylidene) carbohydrazides resulted in a decrease of ...