Deracemization of Quaternary Stereocenters by Pd??Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β??Ketoesters

JT Mohr, DC Behenna, AM Harned…

Index: Mohr, Justin T.; Behenna, Douglas C.; Harned, Andrew M.; Stoltz, Brian M. Angewandte Chemie - International Edition, 2005 , vol. 44, # 42 p. 6924 - 6927

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Citation Number: 240

Abstract

Enantioconvergent catalysis is a powerful synthetic method that converts a racemic stereogenic substrate into an enantiomerically enriched product with a theoretical yield of 100% in a single operation.[1] Conceptually, a catalytic system for such a reaction must achieve a stereomutation [2] or stereoablation [3, 4] of the substrate (or an intermediate), followed by an enantioselective conversion into product (Figure 1, compare pathways I ...