Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives

F Leroux, BJ Van Keulen, J Daliers, N Pommery…

Index: Leroux; Van Keulen; Daliers; Pommery; Henichart Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 509 - 516

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Citation Number: 16

Abstract

A series of triazine derivatives was synthesized. The compounds were evaluated for tracheal smooth muscle relaxant and type 4 phosphodiesterase inhibitory activities. A highly significant correlation was observed between the two effects. Two compounds exhibited potent relaxant activity (EC50: 17 and 24nM) and might be useful for the treatment of asthma.