Synthesis and antihypertensive activity of 6, 7-disubstituted trans-4-amino-3, 4-dihydro-2, 2-dimethyl-2H-1-benzopyran-3-ols

…, TC Hamilton, RH Poyser, GA Showell

Index: Evans, John M.; Fake, Charles S.; Hamilton, Thomas C.; Poyser, Robert H.; Showell, Graham A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1127 - 1131

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Citation Number: 53

Abstract

A series of novel 6, 7-disubstituted trans-3, 4-dihydro-2, 2-dimethyl-4-pyrrolidino-(or piperidino)-Wl-benzopyran-3-01~ was prepared and tested for antihypertensive activity in the conscious spontaneously hypertensive rat (SHR) and compared with certain of their monosubstituted analogues. The potent blood pressure lowering activity of the 6- monosubstituted compounds was enhanced by incorporation of an acetylamino or amino ...