New analgesic drugs derived from phencyclidine

…, A Kalir, BA Weissman, S Cohen

Index: Itzhak, Yossef; Kalir, Asher; Weissman, Ben Avi; Cohen, Sasson Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 496 - 499

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Citation Number: 29

Abstract

Method K. Preparation of 3-Phenyl-5, 7-dihydro-S, 5, 7, 7-tetramethylfuro [3, 4c] pyridazine Hydrochloride (&). Using a condenser equipped with a Dean-Stark trap, a mixture of 4- hydroxy-4-(phenylethynyl)-2, 5-dihydro-2, 2, 5, 5-tetramethyl-furan-3 (W-one (2.58 g, 10 mmol), hydrazine (0.32 g, 10 mmol), and pTsOH. H20 (0.19 g, 1" 01) was heated in refluxing toluene (50 mL) for 18 h. After cooling and neutralization with NaHC03, the solution was ...