Helvetica Chimica Acta

Synthese von Nucleosiden aus 2??substituierten Imidazolen

PC Wyss, P Schönholzer, W Arnold

Index: Wyss, Pierre C.; Schoenholzer, Peter; Arnold, Wolf Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1353 - 1366

Full Text: HTML

Citation Number: 1

Abstract

Summary Condensation of the trimethylsilyl derivatives of 2-substituted diethyl and dimethyl imidazole-4, 5-dicarboxylates (3-5 and 7-9) with 1-O-acetyl-2, 3, 5-tri-O-benzoyl-bn- ribofuranose (2) in the presence of trimethylsilyl trifluoromethanesulfonate provided the 2- substituted diethyl and dimethyl I-(2', 3', 5 '-tri-O-ben-zoyl-~-~-ribofuranosyl) imidazole-4, 5- dicarboxylates 10-15. These were treated with ammonia to afford the 2-substituted 1-(P-~- ...