Tetrahedron: Asymmetry

A practical synthesis of ethyl (R)-and (S)-2-hydroxy-4-phenylbutanoate and D-homophenylalanine ethyl ester hydrochloride from L-malic acid

WQ Lin, Z He, Y Jing, X Cui, H Liu, AQ Mi

Index: Lin, Wen-Qing; He, Ze; Jing, Yi; Cui, Xin; Liu, Hui; Mi, Ai-Qiao Tetrahedron Asymmetry, 2001 , vol. 12, # 11 p. 1583 - 1587

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Citation Number: 35

Abstract

With the readily available l-malic acid as starting material, both enantiomers of ethyl 2- hydroxyl-4-phenylbutanoates and d-homophenylalanine ethyl ester hydrochloride were prepared conveniently in excellent optical purity and 64, 53 and 49% overall yield,