Tetrahedron

Synthesis of perfragilin A, B and some analogues

VF Ferreira, A Park, FJ Schmitz, FA Valeriote

Index: Ferreira, Vitor F.; Park, Aeri; Schmitz, Francis J.; Valeriote, Fred A. Tetrahedron, 2003 , vol. 59, # 8 p. 1349 - 1357

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Citation Number: 7

Abstract

Synthesis of the cytotoxic isoquinoline quinone perfragilin A, an improved synthesis of perfragilin B and preparation of some analogues of both these compounds are described. Cytotoxicity evaluation of a number of the products is reported. The regioselectivity in Diels– Alder reactions of differently substituted benzoquinones with 2-aza-1, 3-bis (t- butyldimethylsilyloxy)-1, 3-butadiene is described.