e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
Ligand exchange reaction of sulfoxides in organic synthesis: A new method for generation of magnesium enolates of α-chloro carboxylic acids and their derivatives
Abstract Treatment of α-chloro α-sulfinyl carboxylic acid derivatives with EtMgBr in THF at low temperature gave magnesium enolates of the α-chloro carboxylic acid derivatives. The enolates reacted with ketones and aldehydes to afford aldol compounds (or α, β-epoxy acids) in good yields.
