Tetrahedron: Asymmetry

Synthesis of ortho-phenyl substituted MeO-BIPHEP ligand and its application in Rh-catalyzed asymmetric hydrogenation

S Wu, M He, X Zhang

Index: Wu, Shulin; He, Minsheng; Zhang, Xumu Tetrahedron Asymmetry, 2004 , vol. 15, # 14 p. 2177 - 2180

Full Text: HTML

Citation Number: 33

Abstract

A new BIPHEP-type ligand with phenyl groups at the 3, 3′-positions, o-Ph-MeO-BIPHEP 3 was prepared. This ligand afforded excellent enantioselectivities when used in the Rh- catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives. The strong influence of o-phenyl groups of the ligand on the enantioselectivities of the reaction has been demonstrated by a comparison with its parent ligand MeO-BIPHEP.