Abstract The use of 1-fluoro-4-hydroxy-1, 4-diazoniabicyclo [2.2. 2] octane bis (tetrafluoroborate)(Accufluor TM NFTh) as a fluorine atom transfer reagent and methanol as solvent enabled direct regiospecific fluorofunctionalization of the α-carbonyl position in ketones without prior activation of the target molecules. Methoxy or hydroxy substituted derivatives of 1-indanone, 1-tetralone and oxo derivatives of thiophene, benzo [b] ...