… of a series of potent inhibitors of human papillomavirus type-11 E1–E2 protein–protein interaction: a combined medicinal chemistry, NMR and computational chemistry …

…, E Malenfant, J Naud, WW Ogilvie, J O'Meara…

Index: Goudreau, Nathalie; Cameron, Dale R.; Deziel, Robert; Hache, Bruno; Jakalian, Araz; Malenfant, Eric; Naud, Julie; Ogilvie, William W.; O'Meara, Jeff; White, Peter W.; Yoakim, Christiane Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2690 - 2700

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Citation Number: 27

Abstract

We have previously reported the discovery and initial SAR optimization of the first series of inhibitors of the human papillomavirus type-11 (HPV11) E1–E2 protein–protein interaction. These inhibitors featured an indandione system spiro-fused onto an all syn substituted tetrahydrofuran ring. In this paper, we report new SAR efforts which have led to the identification of the first low nanomolar inhibitor of the HPV11 E1–E2 protein–protein ...