2-Phenylquinazolin-4 (3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

H Duan, J Zheng, Q Lai, Z Liu, G Tian, Z Wang…

Index: Duan, Hongliang; Zheng, Jin; Lai, Qinglin; Liu, Zheng; Tian, Guanghui; Wang, Zhen; Li, Jianfeng; Shen, Jingshan Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2777 - 2779

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Citation Number: 10

Abstract

In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4 (3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.