Tetrahedron letters

Facile synthesis of 3-trimethylsilylindazoles by [3+ 2] cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes

Y Shoji, Y Hari, T Aoyama

Index: Shoji, Yoshimichi; Hari, Yoshiyuki; Aoyama, Toyohiko Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1769 - 1771

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Citation Number: 22

Abstract

Indazole is well known as an aza analogue of indole, and a number of indazole derivatives have powerful pharmacological activities, for example, anti-inflammatory, anti-tumor, anti-HIV, anti-depressant, and contraceptive activities, etc. 1 Various methods for the preparation of indazoles have been reported. The cyclization of o-methylbenzenediazonium salts, 2 N-(2-nitrobenzylideneamines), 3 o-methyl-N-nitrosoanilines, 4 and o-acylarylhydrazines ...