Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs

…, FX Chen, R Shikiya, LA Marky, B Gold

Index: Li, Jian-Sen; Chen, Fa-Xian; Shikiya, Ronald; Marky, Luis A.; Gold, Barry Journal of the American Chemical Society, 2005 , vol. 127, # 36 p. 12657 - 12665

Full Text: HTML

Citation Number: 30

Abstract

Stable DNA triple-helical structures are normally restricted to homopurine sequences. We have described a system of four heterocyclic bases (TRIPsides) that, when incorporated into oligomers (oligoTRIPs), can recognize and bind in the major groove to any native sequence of DNA [Li et al., J. Am. Chem. Soc. 2003, 125, 2084]. To date, we have reported on triplex- forming oligomers composed of two of these TRIPsides, ie, antiTA and antiGC, and their ...