Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity

S Gallo, S Atifi, A Mahamoud, C Santelli-Rouvier…

Index: Gallo, Sandrine; Atifi, Siham; Mahamoud, Abdallah; Santelli-Rouvier, Christiane; Wolfart, Krisztina; Molnar, Jozsef; Barbe, Jacques European Journal of Medicinal Chemistry, 2003 , vol. 38, # 1 p. 19 - 26

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Citation Number: 33

Abstract

Broad spectrum resistance to chemotherapy in human cancer has been called multidrug resistance [1]. Human P-glycoprotein (P-gp) is related to multidrug resistance and causes a decrease of drug accumulation by an energy ATP dependent efflux. Besides verapamil (VP) [2], a large number of substances have shown the capacity—when added to the anticancer drug—to restore its former activity. Those agents acting as resistance reversal agents have unrelated chemical ...