Compounds 8a–d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as 11 C and 18 F radiotracers, respectively. ... In our laboratory, MC18 and MC113 have been designed as P-gp ligands and their biological evaluation classified them as potent and selective P-gp inhibitors; 8 and 9 thus, these ligands have been [ 11 ...
