Synthesis of Novel Isoxazolyl 1, 6-Dithia-4, 9-diazaspiro [4, 4] nonane-3, 8-diones and 1-Oxa-6-thia-2, 4, 9-triazaspiro [4, 4] non-2-ene-8-ones

E Rajanarendar, S Raju, ASR Reddy

Index: Rajanarendar; Raju; Reddy, A. Siva Rami Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 12 p. 3139 - 3148

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Abstract

The key intermediates, 3-(5-methyl-3-isoxazolyl)-2-arylimino-1, 3-thiazolan-4-ones (3), were obtained from 3-amino-5-methylisoxazole (1) by reaction with chloroacetyl chloride followed by treatment with aryl isothiocyanates. Cyclocondensation of 3 with mercapto acetic acid furnished novel isoxazolyl 1, 6-dithia-4, 9-diazaspiro [4, 4] nonane-3, 8-diones (4). Cycloaddition of 3 with benzonitrile oxides afforded novel isoxazolyl 1-oxa-6-thia-2, 4, 9- ...