Efficient synthesis of some novel spiro heterocycles containing triazine nucleus and their microbiological activity

VV Dabholkar, T Dilip Ravi

Index: Dabholkar, Vijay V.; Ravi, Tripathi Dilip Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 5 p. 593 - 597

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Citation Number: 8

Abstract

Abstract: The compound 4-[(2, 4-substituted benzylidine)-amino]-3-thioxo-1, 2, 4-triazin-5- one 2 is treated with bromine in glacial acetic acid to yield, 4-[(2, 4-substituted benzylidine)- amino]-6, 6-dibromo-3-thioxo-1, 2, 4-triazin-5-one 3. The dibromo compound 3 is then subjected to reaction with substituted triazoles and amino thiophenol to furnish, 1-thia-2, 3- (3′-substituted)-triazolo-4, 6, 7, 9-tetraza-4, 6, 7-trihydro-8-thioxo-10-oxo-9 [(2"/4" ...