Preparation and antiarthritic activity of new 1, 5-diaryl-3-alkylthio-1H-1, 2, 4-triazoles and corresponding sulfoxides and sulfones

G Szilágyi, T Somorai, É Bozó, J Langó, G Nagy…

Index: Szilagyi, Geza; Somorai, Tamas; Bozo, Eva; Lango, Jozsef; Nagy, Gabor; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 2 p. 95 - 101

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Citation Number: 20

Abstract

Abstract A series of 1, 5-diaryl-3-alkylthio-1H-1, 2, 4-triazoles and corresponding sulfoxides and sulfones was synthesized and evaluated as antiinflammatory agents in the rat adjuvant induced arthritis assay. Several analogues were found to be more potent than phenylbutazone and naproxen. Structure-activity relationships are discussed.