European journal of medicinal chemistry

Synthesis and biological evaluation of amide derivatives of (5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-yl) acetic acid as anti-inflammatory agents with reduced …

M Sharma, SM Ray

Index: Sharma, Meenakshi; Ray European Journal of Medicinal Chemistry, 2008 , vol. 43, # 10 p. 2092 - 2102

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Citation Number: 20

Abstract

A variety of amide derivatives of (5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-yl) acetic acid were synthesized and screened for their analgesic and anti-inflammatory activities. The compounds were found to have longer activity profile exceeding that of indomethacin in carrageenan-induced rat paw edema model. Few selected compounds were also screened for their antipyretic, anti-arthritic and ulcerogenecity potential. From these studies it can be ...