Tetrahedron

Deoxyharringtonine, a new antitumor alkaloid from Cephalotaxus: structure and synthetic studies

KL Mikolajczak, RG Powell, CR Smith

Index: Mikolajczak,K.L. et al. Tetrahedron, 1972 , vol. 28, p. 1995 - 2001

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Citation Number: 72

Abstract

A new alkaloid (proposed name, deoxyharringtonine) with significant antileukemic activity has been isolated from Cephalotaxus harringtonia (Forbes) K. Koch var. harringtonia cv. Fastigiata. Its structure has been established as either 2 or 3 by chemical and spectral methods. Total synthesis of the dicarboxylic acid side chain and esterification of its primary carboxyl group with natural cephalotaxine (1) yields 3: therefore, deoxyharringtonine must ...

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