Abstract Studies on benzylation of hydrophilic carbohydrate derivatives with benzyl chloride, using a phase-transfer technique, have led to the conclusion that alkylation of a substrate can be greatly facilitated by the introduction of a “co-catalyst”(eg a tertiary alcohol) and/or a co-solvent (eg DMSO) to the reaction mixture. Efficient procedures for benzylation of sugar derivatives having three to eight hydroxyl groups per molecule, in a two-phase system ...
