Tetrahedron letters

Utilization of O-xylylene N, N-diethylphosphoramidite for the synthesis of phosphoric diesters

Y Watanabe, Y Komoda, S Ozaki

Index: Watanabe, Yutaka; Komoda, Yasunobu; Ozaki, Shoichiro Tetrahedron Letters, 1992 , vol. 33, # 10 p. 1313 - 1316

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Citation Number: 16

Abstract

Abstract o-Xylylene alkyl phosphites which were derived by the reaction of alcohols with o- xylylene N, N-diethylphosphoramidite in the presence of 1H-tetrazole were reacted with second alcohols in the presence of pyridinium bromide perbromide, and a tert-amine, to give the corresponding triesters involving phospholipids. The esters were deprotected to phosphoric diesters by hydrogenolysis or the reaction with disodium disulfide.