Synthesis of 3-arylcoumarins via Suzuki-cross-coupling reactions of 3-chlorocoumarin

…, S Vazquez-Rodriguez, F Borges, L Santana…

Index: Matos, Maria Joao; Vazquez-Rodriguez, Saleta; Borges, Fernanda; Santana, Lourdes; Uriarte, Eugenio Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1225 - 1227

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Citation Number: 36

Abstract

A convenient, new, and effective protocol for a rapid synthesis of different substituted 3- arylcoumarins is reported. The developed synthetic route involves Pd-catalyzed cross- coupling reaction, using a catalytic complex Pd-salen. Under these conditions, a series of different substituted boronic acids have been successfully reacted with a coumarin halide to afford the coupling products in good yields.