Chemistry Letters

Lyophilization of lipase together with ionic compounds generates highly enantioselective and solvent-sensitive lipase in organic solvents

S Ueji, S Mori, H Yumoto, N Hiroshima, Y Ebara

Index: Ueji, Shin-Ichi; Mori, Shu-Ichi; Yumoto, Hiromi; Hiroshima, Naomi; Ebara, Yasuhito Chemistry Letters, 2005 , vol. 34, # 1 p. 110 - 111

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Citation Number: 7

Abstract

The lyophilization of lipase from aqueous enzyme solution containing ionic compounds such as disodium hydrogenphosphate resulted in a dramatic improvement of its enantioselectivity for esterification in organic solvents, compared with the ionic compound-free lipase. The enantioselectivity of the ionic compound-coated lipase was found to be fairly sensitive to the change of the solvents.