ARKIVOC

Natural feedstocks for diversity-oriented synthesis: macrolide-like scaffolds from nonactate

…, SC Bergmeier, MC McMills, ND Priestley, DL Wright

Index: Sumskaya, Yuliya G.; Swain, P. Whitney; Bergmeier, Stepehen C.; McMills, Mark C.; Priestley, Nigel D.; Wrighta, Dennis L. Arkivoc, 2011 , vol. 2011, # 5 p. 144 - 166

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Abstract

Abstract We have been interested in the application of readily available, fermentation- derived natural products as key building blocks for the preparation of natural product-like libraries rich in structural and stereochemical diversity. In this manuscript we describe the conversion of methyl nonactate, derived from nonactin, to a diversable scaffold characteristic of macrolide natural products. The synthesis features a key ring-closing metathesis ...