Antiviral research

Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug …

MA Cheek, ML Sharaf, MI Dobrikov, BR Shaw

Index: Cheek, Marcus Adrian; Sharaf, Mariam L.; Dobrikov, Mikhail I.; Shaw, Barbara Ramsay Antiviral Research, 2013 , vol. 98, # 2 p. 144 - 152

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Citation Number: 5

Abstract

Improved treatments for chronic HCV infections remain a challenge, and new chemical strategies are needed to expand the current paradigm. The HCV RNA polymerase (RdRP) has been a target for antiviral development. For the first time we show that the boranophosphate (BP) modification increases the substrate efficiency of ATP analogs into HCV NS5BΔ55 RdRP-catalyzed RNA. Boranophosphate nucleotides contain a borane ( ...