Molecules

Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase

N Khunnawutmanotham, N Chimnoi, P Saparpakorn…

Index: Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Saparpakorn, Patchareenart; Pungpo, Pornpan; Louisirirotchanakul, Suda; Hannongbua, Supa; Techasakul, Supanna Molecules, 2007 , vol. 12, # 2 p. 218 - 230

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Citation Number: 6

Abstract

Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8- arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.