Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect

…, S Malhotra, H Dhir, A Kumar, A Sharma

Index: Bali, Alka; Malhotra, Sarika; Dhir, Himjyoti; Kumar, Anil; Sharma, Ajay Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3041 - 3044

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Citation Number: 22

Abstract

A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was ...